A panelist discusses how tumor heterogeneity (both spatial and temporal) affects molecular testing reliability in ovarian cancer, highlighting that although most biomarkers show little heterogeneity, ...

Biopsy-derived organoids, accurate models of disease, are used to search for new drugs. Now, results obtained by a study led ...

What innovative approaches in imaging are you seeing advancing immuno-oncology? Two innovations stand out, and they are not mutually exclusive. Molecular imaging, such as PET, utilizes specific ...

In recognition of Breast Cancer Awareness Month, join us for a live webinar to uncover the complexity of tumor biology and the surprising resilience of normal tissue. This event will feature two ...

(a) Schematic of IHoM and IHeM models. NC: neutral cells; AC: cells carrying antigen mutations; IC: immune-recognizable cells; EC: immune-escaped cells. (b) Response of IHoM and IHeM to monotherapies ...

The challenge is that the tumor immune microenvironment is not a static backdrop but a constantly shifting ecosystem shaped by cancer cells, immune cells, stromal cells, cytokines, and physical ...

Recently, a research team led by Prof. Wang Hongzhi from the Hefei Institutes of Physical Science, Chinese Academy of ...

Extrachromosomal DNAs (ecDNAs) are circular DNA structures located in the nuclei of cells outside chromosomes. They were originally discovered in chromosome spreads of cells obtained from embryonal ...

The 2026 NCCN Bladder Cancer Guidelines incorporate the IBCG five-factor model, introducing standardized risk stratification for intermediate-risk NMIBC. For decades, heterogeneity in ...

Cancer plasticity refers to the remarkable ability of cancer cells to alter their identity, function, and behavior in response to environmental stressors or therapeutic pressures. This dynamic trait ...